Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling
نویسندگان
چکیده
منابع مشابه
Polychlorinated biphenyls (PCBs)
rd HJ. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. et al. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools. AD. Th...
متن کاملPredicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling
Benzo[a]pyrene (BaP) is a by-product of incomplete combustion of fossil fuels and plant/wood products, including tobacco. A physiologically based pharmacokinetic (PBPK) model for BaP for the rat was extended to simulate inhalation exposures to BaP in rats and humans including particle deposition and dissolution of absorbed BaP and renal elimination of 3-hydroxy benzo[a]pyrene (3-OH BaP) in huma...
متن کاملUsing Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation
Observation of a clinical event can spur reflective thinking on its source. In pharmacology, adverse events are examples of observations for which deriving the cause is important. Moving from observation to mechanistic understanding requires the use of tools that explicitly delineate biological systems, mode of action, and disease pathophysiology. By expanding understanding of biological factor...
متن کاملInterspecies extrapolation by physiologically based pharmacokinetic modeling
Recently, Christoph Thiel and colleagues from Aachen University published an improved physiologically based pharmacoki-netik modeling (PBPK) technique for mouse to human extrapolation (Thiel et al., 2015). This publication will be awarded by the Ebert Prize 2016 of the American Pharmacist Association, which represents the oldest pharmacy award in the United States. The translation of preclinica...
متن کاملUnraveling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling
Physiologically based pharmacokinetic (PBPK) models integrate both chemical- and system-specific information into a mathematical framework, offering a mechanistic approach to predict the internal dose metrics of a chemical and an ability to perform species and dose extrapolations. Bisphenol A (BPA), because of its ubiquitous presence in a variety of consumer products, has received a considerabl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Exposure Science & Environmental Epidemiology
سال: 2006
ISSN: 1559-0631,1559-064X
DOI: 10.1038/sj.jes.7500540